Dr. Vincent Chen

Dr. Vincent Chen, BSc, PhD (Assistant Professor)
Director, Brandon University Proteomics Centre
Department of Chemistry

Brandon University
Room 4-11, John R.  Brodie Science Centre
270 – 18th Street
Brandon, Manitoba
R7A 6A9

Phone: (204) 727-9775
Fax: (204) 728-7346
Email: chenv@brandonu.ca

Web: www.chenlab.ca

Publications:

14. S. Chittaranjan, S. Chan, C. Yang, K.C. Yang, V.C. Chen, A. Moradian, M. Firme, J. Song, N. Go, M. Blough, J. Chan, G. Cairncross, S.M. Gorski, G. Morin, S. Yip, M.A. Marra. (2014). Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity. Oncotarget, 5(17), 7960-7979.

13. V.C. Chen, J.W. Gouw, C.C. Naus, L.J. Foster. (2013) Connexin Multisite Phosphorylation: Mass spectrometry‐based Proteomics Fills the Gap. BBA – Biomembranes. 1828(1): 23–34.

12. P.R. Gielen, Q. Aftab, N. Ma, V.C. Chen, X. Hong, S. Lozinsky, C.C. Naus, W.-C. Sin (2013) Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway. Neuropharmacology. doi: 10.1016/j.neuropharm.2013.05.002.

11. V.C. Chen, A.R. Kristensen, L.J. Foster, C.C. Naus. (2012) The Association of Cx43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control. J Proteome Res. 7;11(12):6134-46.

10. C. Lamiche, J. Clarhaut, P.-O. Strale,  S. Crespin, N. Pedretti, F.-X. Bernard, C.C. Naus, V.C. Chen, L.J. Foster, N. Defamie, M. Mesnil, F. Debiais, L. Cronier  (2012) The gap junction protein Cx43 is involved in the bone-targeted metastatic behavior of human prostate cancer cells. Clinical & Experimental Metastasis. 29:111–122.

9. V.C. Chen, G. Sadler, M.E. McComb, H. Perreault, H.W. Duckworth (2011) Characterization of specific binding by mass spectrometry: Associations of E. coli citrate synthase with NADH and 2-azidoATP. Int. Journal Mass Spectrometry. 305:238–246.

8. S. Shojania, G.D. Henry, V.C. Chen, T.N. Vo, H. Perreault, J.D. O’Neil (2010) High yield expression and purification of HIV-1 Tat1-72 for structural studies. J. Virology Methods. 164:35-42.

7. V.C. Chen, C.-C. Chou, H.-Y. Hsieh, H. Perreault, K.-H. Khoo (2008). Targeted identification of phosphorylated peptides by Off-line HPLC-MALDI-MS/MS using LC Retention Time Prediction. Journal Mass Spectrometry. 43:1649-58.

6. E. Lattova, V.C. Chen, S. Varma, T. Bezaheh, H. Perreault (2007) Matrix-assisted laser desorption/ionization on-target method for the investigation of oligosaccharides and glycosylation sites in glycopeptides and glycoproteins. Rapid Communication Mass Spectrometry. 21:1644-1650.

5. S. Snovida, V.C. Chen, Perreault, H. (2006) Use of a novel DHB/aniline MALDI matrix for improved detection and on-target derivatization of glycans. Analytical Chemistry. 78:8561-8568.

4. V.C. Chen, X. Li, H. Perreault, J.I. Nagy (2006) Interaction of zonula occludens-1 (ZO-1) with α-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins. Journal Proteome Research. 9:2123-2134.

3. S.I. Snovida, V.C. Chen, O. Krokhin, H. Perreault (2006) Isolation and identification of sialylated glycopeptides from bovine α1-acid glycoprotein by off-line capillary electrophoresis MALDI-TOF mass spectrometry. Analytical Chemistry. 78:6556-6563.

2. V.C. Chen, K. Cheng, W. Ens, K.G. Standing, J.I. Nagy, and H. Perreault. (2004) Device for the reverse-phase separation and on-target deposition of peptides incorporating a novel hydrophobic sample barrier for MALDI mass spectrometry. Analytical Chemistry. 76:1189-1196.

1. V. Pham, W. Zang, V.C Chen, Whitney, T., Yao, J., Froese, D., Friesen, A.D.,
 Diakur, J.M., and Haque, W. (2003) Design and synthesis of novel pyridoxine 5’
-phosphonates as potential anti-ischemic agents. Journal of Medicinal Chemistry. 46:3680-3687.